The continual growth of industry clusters in both the United States and European Union has contributed to a dynamic transatlantic economic landscape. To help further this transatlantic trade, investment, and innovation collaboration, German-American Chamber of Commerce Midwest organizes the Transatlantic Cluster Initiative. The Transatlantic Cluster Initiative connects German and American cluster organizations in order to promote knowledge exchange through specialized, content driven events throughout the United States and Germany.

The exchange focuses on best practices in key topic areas including cluster management, internationalization, skilled workforce recruitment, technological development, etc., and is supported by the German Federal Ministry for Economic Affairs and Energy through the European Recovery Program.